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Newly Developed Covid-19 test in the US claims to identify all variants in hours.

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jhSAAAAAElFTkSuQmCC Newly Developed Covid-19 test in the US claims to identify all variants in hours.

Scientists in the US have developed a rapid COVID-19 test that can accurately detect all current variants of SARS-CoV-2 within hours.

The test, CoVarScan, detects the signatures of eight hotspots on the SARS-CoV-2 virus that causes COVID-19.

The University of Texas (UT) Southwestern Medical Center researchers in the US tested CoVarScan on samples collected from more than 4,000 patients.

The research, published recently in the journal Clinical Chemistry, shows that the test is as accurate as other methods used to diagnose COVID-19, and can successfully differentiate between all current variants of SARS-CoV-2.

While a number of other tests for Covid-19 exist, they generally detect either a fragment of SARS-CoV-2 genetic material or small molecules found on the surface of the virus and don’t provide information to identify the variant.

CoVarScan hones in on eight regions of SARS-CoV-2 that commonly differ between viral variants.

It detects small mutations — where the sequence of RNA building blocks varies — and measures the length of repetitive genetic regions that tend to grow and shrink as the virus evolves.

The method relies on polymerase chain reaction (PCR) — a technique common in most pathology labs — to copy and measure the RNA at these eight sites of interest.

SoRelle’s team ran the test on over 4,000 Covid-19-positive nasal swab samples collected at UT Southwestern from April 2021 to February 2022 — from patients with and without symptoms.

Compared to whole-genome sequencing, CoVarScan had 96 per cent sensitivity and 99 per cent specificity.

It identified and differentiated Delta, Mu, Lambda, and Omicron variants of Covid-19, including the BA.2 version of Omicron, once known as “stealth Omicron” because it did not show up on some tests designed to detect only the Omicron strain.

“A common critique of this kind of test is that it requires constant adjustment for new variants, but CoVarScan has not needed any adjustment in more than a year; it is still performing very well,” said SoRelle.

“In the future, if we did need to adjust it, we could easily add as many as 20 or 30 additional hotspots to the test,” he added.

SoRelle plans to continue developing CoVarScan as a commercial test and has a pending patent application based on this work.

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